Simultaneous Estimation of Ambroxol Hydrochloride and Loratadine in Tablet Dosage Form by Using Uv Spectrophotometric Method
نویسندگان
چکیده
A novel, simple, rapid, precise, accurate, cost effective and reproducible spectrophotometric method has been developed for simultaneous estimation of ambroxol hcl and loratadine in combined tablet dosage form. The method employs measurement of absorbance at two wavelengths,308nm and 245nm, of ambroxol and loratadine respectively. Beer ́s law obeyed in the concentration range of 1050μg/ml and 10-50μg/ml for ambroxol and loratadine respectively.. The proposed method is recommended for routine analysis since it is rapid, simple, accurate, and also sensitive and specific. Results of percentage recovery studies confirmed the accuracy of the proposed method. The present uv spectroscopic method was validated following the ICH guidelines.
منابع مشابه
Development and Validation of Dual Wavelength Uv Spectrophotometric Method for Simultaneous Estimation of Ambroxol Hydrochloride and Desloratadine Hydrochloride in Their Combined Tablet Dosage Form
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical dual wavelength spectrophotometric method for the simultaneous determination of Ambroxol Hydrochloride and Desloratadine Hydrochloride in combined tablet dosage form. The principle for dual wavelength method is “the absorbance difference between two points on the mixture spectra is directly proportional ...
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